Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 5/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.53 |
| ▸ | CCNH | P51946 | 4/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 4/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 12/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25528798 | 0.93 | CCNK (0.53) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25523019 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25528330 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30396054 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25529433 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25419507 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25540418 | 0.88 | CCNK (0.56) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25520628 | 0.88 | CCNK (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30396294 | 0.86 | CCNK (0.51) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30397996 | 0.85 | CCNK (0.51) | CCNKCDK12CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |