Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942383 | 0.94 | ALDH1A1 (0.42) | ALDH1A1LMNAHTTKCNH2KDM4E | |
| SCHEMBL5234381 | 0.88 | KCNH2 (0.46) | ALDH1A1LMNAHTTKCNH2KDM4E | |
| SCHEMBL4928593 | 0.86 | KCNH2 (0.53) | ALDH1A1LMNAHTTKCNH2CFTR | |
| SCHEMBL29192036 | 0.84 | KCNH2 (0.56) | ALDH1A1HTTKCNH2 | |
| SCHEMBL9440072 | 0.84 | KCNH2 (0.56) | ALDH1A1HTTKCNH2 | |
| SCHEMBL1462481 | 0.84 | KCNH2 (0.56) | ALDH1A1HTTKCNH2 | |
| SCHEMBL1461158 | 0.84 | KCNH2 (0.56) | ALDH1A1HTTKCNH2 | |
| SCHEMBL11338813 | 0.84 | KCNH2 (0.56) | ALDH1A1HTTKCNH2 | |
| SCHEMBL29457179 | 0.82 | — | — | |
| SCHEMBL14732897 | 0.82 | ALDH1A1 (0.48) | ALDH1A1LMNAHTTKCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |
| WO-2011121469-A1 | 2,4-DISUBSTITUTED PYRIDINES AS PERFUMING INGREDIENTS | FIRMENICH SA (CH) | 2011-10-06 | — | — | WO | disclosed |
| EP-0986560-B1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | KAROBIO AB (SE) | 2004-03-24 | — | — | EP | disclosed |
| US-6080754-A | Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK A/S (DK) | 2000-06-27 | — | — | US | disclosed |
| US-6075036-A | Pyrrolo [2,1,5-cd] indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK (DK) | 2000-06-13 | — | — | US | disclosed |
| EP-0988303-A1 | PYRROLO 2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-29 | — | — | EP | disclosed |
| EP-0986560-A1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055483-A9 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK AS (DK) | 2000-02-03 | — | — | WO | disclosed |
| WO-1998055482-A1 | PYRROLO[2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055483-A1 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |
| US-5084458-A | Bactericides, malaria and antitumor agents | SCHAPER KLAUS JUERGEN (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4997835-A | Bactericides, malaria, antitumor | SCHAPER KLAUS JUERGEN (DE) | 1991-03-05 | — | — | US | disclosed |