Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 18/20 | 0.64 |
| ▸ | CDK2 | P24941 | 18/20 | 0.64 |
| ▸ | KDR | P35968 | 16/20 | 0.64 |
| ▸ | CDK4 | P11802 | 5/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205981 | 0.82 | CDK2 (0.46) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL31726565 | 0.80 | KDR (0.44) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL25243394 | 0.80 | KDR (0.44) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL2148887 | 0.79 | CDK1 (0.54) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL2519755 | 0.78 | CDK2 (1.00) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL25227101 | 0.77 | CDK1 (0.52) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL30397324 | 0.77 | CDK1 (0.52) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL25227102 | 0.77 | CDK1 (0.52) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL25527464 | 0.77 | CDK1 (0.52) | CDK1CDK2KDRCDK4CCNB1 | |
| SCHEMBL30397310 | 0.75 | CDK1 (0.53) | CDK1CDK2KDRCDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |