Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7882466 | 0.80 | KDM4E (0.39) | ALDH1A1SIGMAR1MAPTKDM4ELMNA | |
| SCHEMBL17888254 | 0.76 | HPGD (0.51) | ALDH1A1SIGMAR1POLB | |
| SCHEMBL23501466 | 0.76 | NOTUM (0.45) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4875267 | 0.76 | ALDH1A1 (0.79) | ALDH1A1MAPTKDM4ESLC6A4HTR2A | |
| SCHEMBL2036812 | 0.76 | ALDH1A1 (0.63) | ALDH1A1SIGMAR1MAPTSLC6A4HTR1A | |
| SCHEMBL16984986 | 0.74 | ALDH1A1 (0.61) | ALDH1A1SIGMAR1MAPTSLC6A4HTR1A | |
| SCHEMBL6398248 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MAPTKDM4ESLC6A4HTR2A | |
| SCHEMBL9381303 | 0.73 | ALDH1A1 (0.69) | ALDH1A1MAPTSLC6A4KMT2ASLC6A3 | |
| SCHEMBL6399230 | 0.73 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4ELMNASLC6A4 | |
| SCHEMBL12347384 | 0.73 | ALDH1A1 (0.55) | ALDH1A1MAPTKDM4ESLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365594-A1 | THIENOPYRROLE COMPOUNDS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| US-11661431-B2 | Thienopyrrole compounds | GILEAD SCIENCES, INC. (US) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365594-A1 | THIENOPYRROLE COMPOUNDS | SSB, TPMT, LCP2 | ALDH1A1 2343/4885SIGMAR1 4030/4885MAPT 3260/4885 |
| US-11661431-B2 | Thienopyrrole compounds | SSB, TPMT, LCP2 | ALDH1A1 2343/4885SIGMAR1 4030/4885MAPT 3260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.