Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15221838 | 0.81 | LRRK2 (0.60) | LRRK2CYP1A2ULK1 | |
| SCHEMBL11916190 | 0.80 | LRRK2 (0.44) | LRRK2CYP1A2 | |
| SCHEMBL31725453 | 0.79 | AURKA (0.54) | LRRK2CYP1A2ULK1 | |
| SCHEMBL31725454 | 0.79 | AURKA (0.54) | LRRK2CYP1A2ULK1 | |
| SCHEMBL12149236 | 0.79 | LRRK2 (0.47) | LRRK2CYP1A2ULK1 | |
| SCHEMBL25529238 | 0.77 | ULK1 (0.45) | LRRK2CYP1A2ULK1 | |
| SCHEMBL10297751 | 0.75 | LRRK2 (0.35) | LRRK2CYP1A2ULK1TTK | |
| SCHEMBL21184419 | 0.75 | ULK1 (0.67) | ULK1 | |
| SCHEMBL12688604 | 0.75 | LRRK2 (0.38) | LRRK2CYP1A2ULK1TTK | |
| SCHEMBL14621356 | 0.74 | ULK1 (0.61) | ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |