Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547795 | 0.94 | MET (0.55) | METCYP3A4CLK1 | |
| SCHEMBL2548823 | 0.92 | MET (0.53) | METCYP3A4CLK1 | |
| SCHEMBL2548814 | 0.91 | MET (0.58) | METCYP3A4CLK1 | |
| SCHEMBL2549722 | 0.89 | MET (0.59) | METCYP3A4 | |
| SCHEMBL2552338 | 0.88 | MET (0.55) | METCYP3A4CLK1 | |
| SCHEMBL2552341 | 0.88 | MET (0.60) | METCYP3A4 | |
| SCHEMBL2553079 | 0.88 | MET (0.57) | METCYP3A4 | |
| SCHEMBL2553780 | 0.88 | MET (0.57) | METCYP3A4 | |
| SCHEMBL2572850 | 0.88 | MET (0.60) | METCYP3A4 | |
| SCHEMBL2551322 | 0.88 | MET (0.58) | METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |