Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021949 | 0.84 | ELANE (0.49) | ELANEPARP1EGLN1VEGFAKDM4E | |
| SCHEMBL197253 | 0.80 | ELANE (0.49) | ELANEPARP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3724946 | 0.75 | ELANE (0.48) | ELANEPARP1ALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL8649103 | 0.75 | ELANE (0.51) | ELANEKDM4EALDH1A1SMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL20944983 | 0.73 | ELANE (0.50) | ELANEKDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL25433288 | 0.73 | ELANE (0.43) | ELANEPARP1EGLN1VEGFAKDM4E | |
| SCHEMBL13923526 | 0.73 | ELANE (0.46) | ELANEPARP1EGLN1VEGFAKDM4E | |
| SCHEMBL20338739 | 0.72 | HSD17B10 (0.47) | ELANEPARP1KDM4EALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL761835 | 0.72 | ELANE (0.55) | ELANEPARP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3911656 | 0.72 | ALDH1A1 (0.50) | ELANEKDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833348-B1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA INC (US) | 2023-05-31 | — | — | EP | disclosed |