SCHEMBL2553253

SCHEMBL2553253

CCCCCCCCCCCCCCCCCCOCCOP(=O)(O)COC(COC)Cn1cnc2c(N)nc(N)nc21

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 12/20 0.59
CYP2D6 P10635 11/20 0.59
FGFR1 P11362 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14665350 1.00 CYP3A4 (0.59) CYP3A4CYP2D6FGFR1
SCHEMBL14665313 1.00 CYP3A4 (0.59) CYP3A4CYP2D6FGFR1
SCHEMBL14665311 0.97 CYP3A4 (0.63) CYP3A4CYP2D6FGFR1
SCHEMBL14665317 0.97 CYP3A4 (0.63) CYP3A4CYP2D6FGFR1
SCHEMBL14665315 0.97 CYP3A4 (0.63) CYP3A4CYP2D6FGFR1
SCHEMBL14665360 0.92 CYP3A4 (0.63) CYP3A4CYP2D6FGFR1
SCHEMBL14665372 0.90 CYP2D6 (0.49) CYP3A4CYP2D6
SCHEMBL14665371 0.90 CYP2D6 (0.49) CYP3A4CYP2D6
SCHEMBL16574523 0.89 CYP3A4 (0.73) CYP3A4CYP2D6FGFR1
SCHEMBL14665353 0.89 CYP3A4 (0.73) CYP3A4CYP2D6FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3401320-B1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA UNIV CALIFORNIA (US) 2020-05-13 EP disclosed
US-10449207-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-22 US disclosed
US-20180360859-A1 Acyclic Nucleoside Phosphonate Diesters NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-12-20 US disclosed
EP-3401320-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA The Regents of the University of California (US) 2018-11-14 EP disclosed
US-10076532-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-18 US disclosed
US-10076533-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-18 US disclosed
EP-2970346-B1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS UNIV CALIFORNIA (US) 2018-08-08 EP disclosed
US-20180071323-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-03-15 US disclosed
US-20170304330-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2017-10-26 US disclosed
US-9775852-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-10-03 US disclosed
US-20140364397-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION 2014-12-11 US disclosed
US-8846643-B2 Phosphonates with reduced toxicity for treatment of viral infections THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-09-30 US disclosed
US-8846643-B2 Phosphonates with reduced toxicity for treatment of viral infections THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-09-30 US disclosed
WO-2014143643-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-18 WO disclosed
US-20140275532-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-18 US disclosed
US-8835630-B1 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-16 US disclosed
EP-2558466-A2 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS The Regents of the University of California (US) 2013-02-20 EP disclosed
US-20130029940-A1 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-01-31 US disclosed
US-20130029940-A1 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-01-31 US disclosed
WO-2011130557-A2 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130029940-A1 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS POLRMT, PNP, MTAP CYP3A4 1443/4885CYP2D6 1904/4885FGFR1 3477/4885
US-20180360859-A1 Acyclic Nucleoside Phosphonate Diesters NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-10449207-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-20140275532-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-10076532-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-20170304330-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-20180071323-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-10076533-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885
US-20140364397-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP CYP3A4 3422/4885CYP2D6 3086/4885FGFR1 3394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.