Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2506959 | 0.86 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2505253 | 0.83 | ALDH1A1 (0.46) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12264216 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2505569 | 0.74 | PIK3CD (0.79) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2507120 | 0.74 | PIK3CD (0.79) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2504026 | 0.74 | PIK3CD (0.79) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2504398 | 0.71 | PIK3CD (0.55) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL13495586 | 0.70 | PIK3CA (0.60) | PIK3CDPIK3CAHPGDMAPK14ACSS2 | |
| SCHEMBL12264214 | 0.69 | PIK3CD (0.55) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL11901900 | 0.69 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |