Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896280 | 0.87 | TSHR (0.36) | KDM4AIDO1TSHRALDH1A1POLB | |
| SCHEMBL12206651 | 0.86 | KDM4E (0.42) | KDM4AIDO1TSHRGAAPOLB | |
| SCHEMBL31420797 | 0.85 | EGFR (0.43) | KDM4AHDAC10HDAC6ALDH1A1POLB | |
| SCHEMBL12206607 | 0.84 | KDM4A (0.41) | KDM4AIDO1HDAC10HDAC6ALDH1A1 | |
| SCHEMBL2522260 | 0.84 | NPC1 (0.42) | KDM4AHDAC10HDAC6ALDH1A1GAA | |
| SCHEMBL5413105 | 0.84 | EPHX2 (0.48) | KDM4AIDO1TSHRHDAC10HDAC6 | |
| SCHEMBL27988801 | 0.83 | IDO1 (0.53) | KDM4AIDO1TSHRALDH1A1GAA | |
| SCHEMBL4339307 | 0.83 | KDM4E (0.49) | KDM4ATSHRALDH1A1POLBMEN1 | |
| SCHEMBL12480602 | 0.82 | IDO1 (0.40) | KDM4AIDO1TSHRHDAC10HDAC6 | |
| SCHEMBL2520675 | 0.81 | AAK1 (0.46) | KDM4AIDO1TSHRHDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |
| WO-2011124998-A1 | SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011124998-A1 | SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| US-20110251247-A1 | SUBSTITUTED ISOXAZOLINE DERIVATIVES | PFIZER INC. (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251247-A1 | SUBSTITUTED ISOXAZOLINE DERIVATIVES | PFIZER INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251247-A1 | SUBSTITUTED ISOXAZOLINE DERIVATIVES | CYP4X1, COL1A1, RDX | KDM4A 1421/4885IDO1 276/4885TSHR 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.