COL1A1

Collagen alpha-1(I) chain · P02452 · COL1A1 on Sugi Atlas →

555 patent compounds predicted against COL1A1, 348 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15133348	0.64	12/20
SCHEMBL14865287	0.53	12/20
SCHEMBL28746315	0.50	5/20
SCHEMBL27147420	0.68	4/20
SCHEMBL26192501	0.67	4/20
SCHEMBL27148833	0.66	4/20
SCHEMBL27145904	0.60	4/20
SCHEMBL29958870	0.60	4/20
SCHEMBL26622443	0.59	4/20
SCHEMBL25566771	0.59	4/20
SCHEMBL29222857	0.55	4/20
SCHEMBL30906667	0.55	4/20
SCHEMBL29403903	0.34	4/20
Palmitine (SCHEMBL562120)	0.70	3/20
Palmitine (SCHEMBL29350054)	0.70	3/20
Palmitine (SCHEMBL29471136)	0.70	3/20
Palmitine (SCHEMBL754702)	0.69	3/20
Palmitine (SCHEMBL2445279)	0.69	3/20
Palmitine (SCHEMBL29376263)	0.69	3/20
Palmitine (SCHEMBL29766942)	0.69	3/20

Clinical trials — most relevant to COL1A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Dapagliflozin on Renal Outcomes and Bone Mineral Disease in Non-diabetic Chronic Kidney Disease Patients	PHASE4	COMPLETED
5FU vs 5FU With Viscoelastic Formulation for the Prevention of Scarring Post-trabeculectomy	PHASE4	COMPLETED
Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta	PHASE3	ACTIVE_NOT_RECRUITING
Pamidronate to Treat Osteogenesis Imperfecta in Children	PHASE3	COMPLETED
A Study Comparing Oral Calcitonin to Nasal Spray Calcitonin in Postmenopausal Osteoporotic Women	PHASE3	COMPLETED
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI	PHASE2	COMPLETED
Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN)	PHASE2	RECRUITING
Translational Therapy in Patients With Osteogenesis Imperfecta - A Pilot Trial on Treatment With the Rankl-Antibody Denosumab	PHASE2	COMPLETED
Boost to Brittle Bones - Stem Cell Transplantation for Treatment of Brittle Bones	PHASE1/PHASE2	UNKNOWN
The Benefit of Bermekimab in Patients With Systemic Sclerosis	PHASE2	COMPLETED
Study to Evaluate Pharmacokinetics, Safety, and Tolerability Ildong COL-144 Tablet in Korean Healthy Volunteers	PHASE1	UNKNOWN
Telescoping Nail in Osteogenesis Imperfecta	nan	ACTIVE_NOT_RECRUITING
Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital	nan	NOT_YET_RECRUITING
Resistance Exercise and Hydrolyzed Collagen Supplementation	nan	COMPLETED
Clear Aligners for the Treatment of Dental Malocclusion in OI	nan	ACTIVE_NOT_RECRUITING
Clinical Study on the Application of PET Probes Targeting DDR2 in the Diagnosis of Interstitial Lung Disease With Cognitive Impairment	nan	NOT_YET_RECRUITING
Acute Resistance Exercise and Hydrolyzed Collagen Supplementation	nan	COMPLETED
Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study	nan	COMPLETED
Osteogenesis Imperfecta Blood Pressure Study	nan	COMPLETED
Effect of Thiazolidinediones on Human Bone	nan	COMPLETED
Impact of Comorbidities, Some Biomarkers, Micro RNA in Childhood Asthma Phenotypes	nan	NOT_YET_RECRUITING
Evaluation of High-Purity Type I Collagen Biologic Wrap to Improve Function After Extensor Tendon Repair of the Hand	nan	COMPLETED
Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype Correlation	nan	COMPLETED
Effects of a Dietary Supplement on Collagen Production and Evaluation of Its Regenerative and Anti-Ageing Propertiess	nan	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Fibroblast Line Evaluation for COL5A eXpression and Thoracic Aortic Aneurysms: in Vitro Characterization of Cutaneous Fibroblasts in Adult Patients	nan	NOT_YET_RECRUITING
Impact of the Source and Food Matrices on the Bioavailability of Peptan® (Collagen Peptides) in Healthy Subjects	nan	COMPLETED
Microneedling With Topical Preparations in the Treatment of Atrophic Post-acne Scars	nan	UNKNOWN
Effects of Epicatechin-rich Cocoa on Collagen Synthesis	nan	COMPLETED
Impact of Milk and Yogurt Supplementation on Bone Health, Body Composition, and Gut Microbiota in Canadian Young Adults	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a COL1A1 binder may also engage these)

Protein	Name	Similarity
P11087	—	1.000	P11087 →
Q9XSJ7	—	1.000	Q9XSJ7 →
C0HLG9	—	1.000	C0HLG9 →
P02453	—	1.000	P02453 →
P02457	—	1.000	P02457 →
C0HLH3	—	1.000	C0HLH3 →
COL2A1	Collagen alpha-1(II) chain	1.000	landscape →
P05539	—	0.998	P05539 →
C0HLJ3	—	0.998	C0HLJ3 →
Q6P4Z2	—	0.997	Q6P4Z2 →
P28481	—	0.996	P28481 →
P02459	—	0.996	P02459 →
C0HLI9	—	0.995	C0HLI9 →
C0HLI7	—	0.995	C0HLI7 →
C0HLJ7	—	0.994	C0HLJ7 →
Q91717	—	0.994	Q91717 →
Q9YIB4	—	0.993	Q9YIB4 →
C0HLJ5	—	0.993	C0HLJ5 →
C0HM93	—	0.993	C0HM93 →
C0HJP3	—	0.993	C0HJP3 →
P02454	—	0.993	P02454 →
P0C2W8	—	0.993	P0C2W8 →
C0HLI3	—	0.992	C0HLI3 →
C0HLH9	—	0.992	C0HLH9 →
C0HLH5	—	0.991	C0HLH5 →
C0HLI1	—	0.991	C0HLI1 →
C0HLG7	—	0.991	C0HLG7 →
C0HJN3	—	0.990	C0HJN3 →
P02461	—	0.988	P02461 →
C0HJP7	—	0.988	C0HJP7 →