Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25438402 | 1.00 | IDH1 (0.41) | IDH1PDE4BMAPTSMN1; SMN2STS | |
| SCHEMBL25419655 | 1.00 | IDH1 (0.41) | IDH1PDE4BMAPTSMN1; SMN2STS | |
| SCHEMBL25533413 | 0.91 | USP30 (0.40) | IDH1MAPTSTSEGFRERBB2 | |
| SCHEMBL25234548 | 0.91 | USP30 (0.40) | IDH1MAPTSTSEGFRERBB2 | |
| SCHEMBL26126417 | 0.89 | MAPT (0.45) | IDH1MAPTSTSEGFRERBB2 | |
| SCHEMBL23292270 | 0.83 | USP30 (0.51) | IDH1MAPTSTSCCNKCDK12 | |
| SCHEMBL22895379 | 0.83 | USP30 (0.51) | IDH1MAPTSTSCCNKCDK12 | |
| SCHEMBL28544531 | 0.83 | USP30 (0.51) | IDH1MAPTSTSCCNKCDK12 | |
| SCHEMBL31581627 | 0.81 | HCRTR1 (0.46) | MAPTSMN1; SMN2CCNKCDK12HCRTR1 | |
| SCHEMBL30915078 | 0.80 | ALDH1A1 (0.53) | IDH1MAPTSTSCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |