Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13921182 | 0.88 | CYP4F2 (0.51) | CTSKHTTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4495403 | 0.88 | CYP4F2 (0.51) | CTSKHTTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20768654 | 0.85 | PTPRB (0.47) | SMN1; SMN2MAPTLMNAHTTCYP1A2 | |
| SCHEMBL19331691 | 0.85 | PTPRB (0.47) | SMN1; SMN2MAPTLMNAHTTCYP1A2 | |
| SCHEMBL24675580 | 0.82 | ACACB (0.52) | SMN1; SMN2GAACTSKLMNAACACB | |
| SCHEMBL30916868 | 0.82 | ACACB (0.52) | SMN1; SMN2GAACTSKLMNAACACB | |
| SCHEMBL17524451 | 0.82 | NAMPT (0.53) | SMN1; SMN2CTSKMAPTLMNAHTT | |
| SCHEMBL1724453 | 0.81 | CTSK (0.48) | CTSKMAPTHTTACACBPPARG | |
| SCHEMBL1724454 | 0.81 | CTSK (0.48) | CTSKMAPTHTTACACBPPARG | |
| SCHEMBL14831003 | 0.81 | CTSK (0.48) | CTSKMAPTHTTACACBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |