Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 16/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19343635 | 0.89 | PHGDH (0.55) | PHGDHHSD17B10TP53MAPTSMN1; SMN2 | |
| SCHEMBL19344109 | 0.87 | PHGDH (0.53) | PHGDHHSD17B10TP53MAPTSMN1; SMN2 | |
| SCHEMBL19344152 | 0.87 | PHGDH (0.53) | PHGDHHSD17B10TP53MAPTSMN1; SMN2 | |
| SCHEMBL19347315 | 0.85 | PHGDH (0.59) | PHGDHHSD17B10RXFP1 | |
| SCHEMBL19347345 | 0.84 | PHGDH (0.51) | PHGDHHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL26326346 | 0.84 | PHGDH (0.51) | PHGDHHSD17B10TP53MAPTSMN1; SMN2 | |
| SCHEMBL23366358 | 0.81 | PHGDH (0.48) | PHGDHHSD17B10TP53MAPTSMN1; SMN2 | |
| SCHEMBL31008849 | 0.81 | PHGDH (0.65) | PHGDHTHRBRXFP1TP53 | |
| SCHEMBL20794375 | 0.81 | PHGDH (0.65) | PHGDHTHRBRXFP1TP53 | |
| SCHEMBL23366395 | 0.81 | PHGDH (0.51) | PHGDHHSD17B10THRBRXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |