Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344152 | 0.93 | PHGDH (0.53) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19347345 | 0.88 | PHGDH (0.51) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19343635 | 0.87 | PHGDH (0.55) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19344109 | 0.85 | PHGDH (0.53) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL25538844 | 0.84 | PHGDH (0.57) | PHGDHHSD17B10SMN1; SMN2TP53MAPT | |
| SCHEMBL19347347 | 0.84 | DRD2 (0.46) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19347589 | 0.83 | PHGDH (0.45) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19347346 | 0.82 | PHGDH (0.49) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL20793451 | 0.82 | PHGDH (0.53) | PHGDHKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19342000 | 0.82 | PHGDH (0.44) | PHGDHKDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234552-A2 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |