Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.59 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25540594 | 0.86 | LRRK2 (0.77) | LRRK2ABL1 | |
| SCHEMBL22380363 | 0.83 | LRRK2 (0.78) | LRRK2ABL1 | |
| SCHEMBL23795720 | 0.82 | LRRK2 (0.61) | LRRK2ABL1KDR | |
| SCHEMBL22380088 | 0.82 | LRRK2 (0.79) | LRRK2ABL1KDR | |
| SCHEMBL23795705 | 0.82 | LRRK2 (0.63) | LRRK2ABL1KDR | |
| SCHEMBL25540639 | 0.82 | CSNK1D (0.52) | ABL1KDR | |
| SCHEMBL22380094 | 0.81 | LRRK2 (0.79) | LRRK2ABL1KDR | |
| SCHEMBL23795682 | 0.80 | LRRK2 (0.60) | LRRK2ABL1 | |
| SCHEMBL24012496 | 0.77 | LRRK2 (0.81) | LRRK2ABL1 | |
| SCHEMBL22380059 | 0.75 | ABL1 (0.64) | LRRK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230151001-A9 | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151001-A9 | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF | JAK1, JAK2, JAK3 | LRRK2 2176/4885ABL1 16/4885KDR 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.