SCHEMBL2554319

SCHEMBL2554319

O=Cc1c(-c2ccc(F)c(F)c2)nn(-c2ccccc2F)c1Br

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 2/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
MAOB P27338 1/20 0.33
AR P10275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2557663 0.89 MAPK11 (0.37)
SCHEMBL2555081 0.88 GAA (0.38) KCNN4
SCHEMBL2556011 0.88 ESR1 (0.36) CA1CA2
SCHEMBL2559077 0.87 POLB (0.41) KCNN4
SCHEMBL15331929 0.87 KCNN4 (0.37) KCNN4
SCHEMBL15331900 0.87 PIK3CG (0.37) KCNN4
SCHEMBL15331739 0.86 DHODH (0.35) KCNN4
SCHEMBL15330512 0.86 LMNA (0.38) CA1CA2
SCHEMBL2557352 0.86 CA1 (0.39) CA1CA2AR
SCHEMBL2553185 0.86 KCNN4 (0.35) KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed