Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | WNT1 | P04628 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 3/20 | 0.53 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14332816 | 0.85 | DYRK1A (0.46) | MKNK1GSK3BDYRK1AWNT1F10 | |
| SCHEMBL2554133 | 0.84 | MKNK1 (0.57) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL2560567 | 0.84 | MKNK1 (0.57) | MKNK1GSK3BDYRK1AWNT1F10 | |
| SCHEMBL19296044 | 0.83 | MKNK1 (0.64) | MKNK1GSK3BDYRK1AWNT1F10 | |
| SCHEMBL2560426 | 0.83 | GSK3B (0.62) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL2562533 | 0.83 | GSK3B (0.60) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL2556872 | 0.83 | GSK3B (0.60) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| Hydrochloric Acid SCHEMBL17632594 | 0.82 | MKNK1 (0.63) | MKNK1GSK3BDYRK1AWNT1F10 | |
| Hydrochloric Acid SCHEMBL17632596 | 0.82 | MKNK1 (0.63) | MKNK1GSK3BDYRK1AWNT1F10 | |
| SCHEMBL2554164 | 0.80 | MKNK1 (0.55) | MKNK1GSK3BDYRK1AWNT1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |