Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.62 |
| ▸ | WNT1 | P04628 | 3/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | CASK | O14936 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | PAK3 | O75914 | 1/20 | 0.48 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556872 | 0.88 | GSK3B (0.60) | GSK3BDYRK1AWNT1MKNK1SMN1; SMN2 | |
| SCHEMBL2562533 | 0.88 | GSK3B (0.60) | GSK3BDYRK1AWNT1MKNK1SMN1; SMN2 | |
| SCHEMBL2554560 | 0.83 | MKNK1 (0.58) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| SCHEMBL2554227 | 0.83 | STK17B (0.61) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| SCHEMBL2560567 | 0.82 | MKNK1 (0.57) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| SCHEMBL2554133 | 0.82 | MKNK1 (0.57) | GSK3BDYRK1AWNT1MKNK1SMN1; SMN2 | |
| SCHEMBL19296044 | 0.81 | MKNK1 (0.64) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| Hydrochloric Acid SCHEMBL17632594 | 0.80 | MKNK1 (0.63) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| Hydrochloric Acid SCHEMBL17632596 | 0.80 | MKNK1 (0.63) | GSK3BDYRK1AWNT1MKNK1CDK2 | |
| SCHEMBL17632481 | 0.79 | UCHL1 (0.62) | GSK3BDYRK1AWNT1MKNK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |