Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10943611 | 0.86 | MEN1 (0.50) | L3MBTL1SMN1; SMN2MAPTALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL9617121 | 0.85 | MEN1 (0.49) | L3MBTL1SMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL12560522 | 0.84 | LMNA (0.43) | L3MBTL1SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL18300754 | 0.83 | LMNA (0.38) | L3MBTL1POLBMAPTALDH1A1CYP1A2 | |
| SCHEMBL14338510 | 0.81 | TDP1 (0.54) | L3MBTL1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL21597111 | 0.76 | AURKA (0.52) | SMN1; SMN2POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL8645754 | 0.75 | MAPK1 (0.48) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL18300258 | 0.74 | CA12 (0.33) | L3MBTL1SMN1; SMN2POLBMAPTCYP1A2 | |
| SCHEMBL17517937 | 0.74 | TSHR (0.40) | L3MBTL1SMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL8645750 | 0.73 | HSD17B2 (0.43) | POLBMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158006-A1 | USE OF DIRECT THROMBIN INHIBITORS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | GRAMMAS PAULA (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158006-A1 | USE OF DIRECT THROMBIN INHIBITORS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | GRAMMAS PAULA (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158006-A1 | USE OF DIRECT THROMBIN INHIBITORS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | TFPI, TFPI2, PLAT | L3MBTL1 3201/4885SMN1; SMN2 351/4885POLB 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.