Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553495 | 0.82 | GPR119 (0.61) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL2556341 | 0.82 | GPR119 (0.61) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL12283335 | 0.81 | GPR119 (1.00) | GPR119 | |
| SCHEMBL2555904 | 0.81 | GPR119 (1.00) | GPR119 | |
| SCHEMBL2555906 | 0.81 | GPR119 (1.00) | GPR119 | |
| SCHEMBL14634420 | 0.81 | GPR119 (0.73) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL2556261 | 0.81 | GPR119 (0.73) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL14634426 | 0.81 | GPR119 (0.60) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL14634424 | 0.81 | GPR119 (0.60) | GPR119MAPTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL2554732 | 0.81 | GPR119 (0.72) | GPR119HRH3HRH1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556056-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127051-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | WO | disclosed |