SCHEMBL25546708

SCHEMBL25546708

Cc1cc2c(Cl)nnc(N3CCC(CNC(=O)OC(C)(C)C)CC3)c2cc1C

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACACB O00763 11/20 0.48
ACACA Q13085 9/20 0.48
CKS1B P61024 1/20 0.46
SKP1 P63208 1/20 0.46
SKP2 Q13309 1/20 0.46
DRD2 P14416 2/20 0.45
SUV39H2 Q9H5I1 3/20 0.44
SIRT2 Q8IXJ6 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
SIRT3 Q9NTG7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25548557 0.90 SUV39H2 (0.50) ACACBACACACKS1BSKP1SKP2
SCHEMBL24000748 0.88 CKS1B (0.55) ACACBACACACKS1BSKP1SKP2
SCHEMBL25546714 0.81 ENPP1 (0.52) ACACBACACACKS1BSKP1SKP2
SCHEMBL2385162 0.78 CKS1B (0.49) ACACBACACACKS1BSKP1SKP2
SCHEMBL16449186 0.76 CKS1B (0.52) ACACBACACACKS1BSKP1SKP2
SCHEMBL23107657 0.75 ACACB (0.56) ACACBACACACKS1BSKP1SKP2
SCHEMBL30376168 0.75 CKS1B (0.52) ACACBACACACKS1BSKP1SKP2
SCHEMBL16449187 0.73 CKS1B (0.50) ACACBACACACKS1BSKP1SKP2
SCHEMBL3436642 0.73 CKS1B (0.59) ACACBACACACKS1BSKP1SKP2
SCHEMBL16162195 0.73 MEN1 (0.51) CKS1BSKP1SKP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF ENPP1, ENPP3, PPA1 ACACB 3835/4885ACACA 3344/4885CKS1B 2173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.