Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922469 | 0.79 | CSNK1A1 (0.74) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL12922499 | 0.74 | IGF1R (0.57) | CSNK1A1CLK4 | |
| SCHEMBL975743 | 0.73 | CSNK1A1 (0.76) | CSNK1A1CLK4DHFRADORA2AADORA1 | |
| SCHEMBL10843457 | 0.72 | ADORA2A (0.71) | CSNK1A1CLK4DHFRADORA2AADORA1 | |
| SCHEMBL980758 | 0.72 | CSNK1A1 (0.62) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL976667 | 0.70 | CSNK1A1 (1.00) | CSNK1A1CLK4DHFRADORA2AADORA1 | |
| SCHEMBL25822992 | 0.70 | KMO (0.51) | ADORA2AADORA1CTSSCTSKBACE1 | |
| SCHEMBL778529 | 0.70 | HDAC4 (0.63) | BACE1HDAC4HDAC2HDAC8KMO | |
| SCHEMBL29913254 | 0.69 | HEXA (0.62) | DHFRCYP2D6ADRA1A | |
| SCHEMBL13481022 | 0.69 | ADORA2A (0.74) | CSNK1A1CLK4DHFRADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |