Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520757 | 0.84 | VCP (0.41) | HRH3CYP2D6VCPCYP1A2ALOX15 | |
| SCHEMBL25122685 | 0.84 | HRH3 (0.50) | HRH3CYP2D6KCNH2 | |
| SCHEMBL21019132 | 0.84 | CYP2D6 (0.36) | HRH3CYP2D6KCNH2FFAR4CYP1A2 | |
| SCHEMBL22301106 | 0.83 | CYP2D6 (0.38) | HRH3CYP2D6FFAR4 | |
| SCHEMBL22952327 | 0.81 | CYP2D6 (0.33) | HRH3CYP2D6FFAR4 | |
| SCHEMBL22520604 | 0.80 | HRH3 (0.36) | HRH3CYP2D6 | |
| SCHEMBL24475619 | 0.78 | VCP (0.39) | HRH3CYP2D6VCPCYP1A2ALOX15 | |
| SCHEMBL10111445 | 0.77 | CYP2D6 (0.46) | HRH3CYP2D6VCPCYP1A2 | |
| SCHEMBL15316686 | 0.76 | CYP2D6 (0.37) | HRH3CYP2D6KCNH2 | |
| SCHEMBL31273027 | 0.76 | HRH3 (0.47) | HRH3CYP2D6KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159573-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159573-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | STAT1, STAT3, STAT5A | HRH3 3722/4885CYP2D6 1475/4885KCNH2 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.