⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383731 | 0.89 | TSHR (0.32) | — | |
| SCHEMBL4818972 | 0.87 | TSHR (0.31) | — | |
| SCHEMBL16504168 | 0.85 | TSHR (0.30) | — | |
| SCHEMBL2621446 | 0.85 | TSHR (0.30) | — | |
| SCHEMBL14136628 | 0.85 | TSHR (0.30) | — | |
| SCHEMBL23139033 | 0.82 | — | — | |
| SCHEMBL10030503 | 0.82 | TSHR (0.35) | — | |
| SCHEMBL21395330 | 0.82 | TSHR (0.31) | — | |
| SCHEMBL19364625 | 0.82 | — | — | |
| SCHEMBL23823738 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250304613-A1 | AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE CONJUGATION APPROACH | ALNYLAM PHARMACEUTICALS, INC. (US) | 2025-10-02 | — | — | US | disclosed |
| US-20250207131-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2025-06-26 | — | — | US | disclosed |
| US-12275938-B2 | Modified RNA agents with reduced off-target effect | ALNYLAM PHARMACEUTICALS, INC. (US) | 2025-04-15 | — | — | US | disclosed |
| US-12247203-B2 | Modified RNA agents with reduced off-target effect | ALNYLAM PHARMACEUTICALS, INC. | 2025-03-11 | — | — | US | disclosed |
| EP-4367125-A1 | AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH | Alnylam Pharmaceuticals, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283434-A9 | AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH | ALNYLAM PHARMACEUTICALS, INC. (US) | 2024-03-28 | — | — | WO | disclosed |
| WO-2023283434-A1 | AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-01-12 | — | — | WO | disclosed |
| US-20220290145-A1 | Modified RNA Agents with Reduced Off-Target Effect | ALNYLAM PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| US-20210238595-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| US-10131908-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-5824796-A | MEDICAL DIAGNOSIS WITH TARGET DNA OR RNA FOR ENZYME INHIBITORS | EPOCH PHARMACEUTICALS, INC. (US) | 1998-10-20 | — | — | US | disclosed |
| EP-0637314-B1 | N-ACYLATED 2'-DEOXYCYTIDINES USEFUL IN OLIGONUCLEOTIDE SYNTHESIS | BECKMAN INSTRUMENTS INC (US) | 1998-06-24 | — | — | EP | disclosed |
| EP-0843684-A2 | UNIVERSAL SOLID SUPPORTS AND METHODS FOR THEIR USE | BECKMAN INSTRUMENTS, INC. (US) | 1998-05-27 | — | — | EP | disclosed |
| US-5726301-A | ADDITION OF DEOXYCYTIDINE FOR OLIGONUCLEOTIDES | BECKMAN INSTRUMENTS, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1997040458-A2 | UNIVERSAL SOLID SUPPORTS AND METHODS FOR THEIR USE | BECKMAN INSTRUMENTS, INC. (US) | 1997-10-30 | — | — | WO | disclosed |
| US-5623068-A | Synthesis of DNA using substituted phenylacetyl-protected nucleotides | BECKMAN INSTRUMENTS, INC. (US) | 1997-04-22 | — | — | US | disclosed |
| US-5616700-A | GENETIC ENGINEERING | BECKMAN INSTRUMENTS, INC. (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0749436-A1 | COMPOSITIONS AND METHODS FOR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES | BECKMAN INSTRUMENTS, INC. (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024413-A1 | COMPOSITIONS AND METHODS FOR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES | BECKMAN INSTRUMENTS, INC. (US) | 1995-09-14 | — | — | WO | disclosed |
| US-5428148-A | Reduced side product formation | BECKMAN INSTRUMENTS, INC. (US) | 1995-06-27 | — | — | US | disclosed |