Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576731 | 0.95 | MET (0.65) | METCYP3A4HTTALDH1A1MAPT | |
| SCHEMBL2552341 | 0.93 | MET (0.60) | METCYP3A4 | |
| SCHEMBL2578575 | 0.91 | MET (0.59) | METCYP3A4HTTALDH1A1MAPT | |
| SCHEMBL2572850 | 0.90 | MET (0.60) | METCYP3A4 | |
| SCHEMBL2547941 | 0.90 | MET (0.56) | METCYP3A4 | |
| SCHEMBL2554228 | 0.89 | MET (0.68) | METCYP3A4 | |
| SCHEMBL2551322 | 0.88 | MET (0.58) | METCYP3A4 | |
| SCHEMBL2549722 | 0.88 | MET (0.59) | METCYP3A4 | |
| SCHEMBL2554825 | 0.86 | MET (0.56) | METCYP3A4 | |
| SCHEMBL2576078 | 0.86 | MET (0.59) | METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | claimed |
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |