Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552284 | 0.93 | MET (0.66) | METCYP3A4 | |
| SCHEMBL2550247 | 0.93 | MET (0.64) | METCYP3A4 | |
| SCHEMBL2551912 | 0.89 | MET (0.60) | METCYP3A4 | |
| SCHEMBL2570392 | 0.89 | MET (0.63) | METCYP3A4 | |
| SCHEMBL2549710 | 0.88 | MET (0.73) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2554270 | 0.86 | MET (0.63) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL3719030 | 0.86 | MET (0.70) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2800569 | 0.86 | MET (0.70) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2549722 | 0.86 | MET (0.59) | METCYP3A4 | |
| SCHEMBL2763443 | 0.85 | MET (1.00) | METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | claimed |
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |