Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14633467 | 0.99 | KCNH2 (0.42) | SSTR5 | |
| Hydrochloric Acid SCHEMBL2554746 | 0.94 | KCNH2 (0.41) | SSTR5 | |
| SCHEMBL2553797 | 0.92 | CCR3 (0.47) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL14633841 | 0.91 | CCR3 (0.46) | HTR2A | |
| SCHEMBL2551227 | 0.89 | SLC6A2 (0.47) | — | |
| Hydrochloric Acid SCHEMBL14633798 | 0.88 | SLC6A2 (0.46) | — | |
| SCHEMBL2557120 | 0.87 | CCR3 (0.46) | HTR2A | |
| SCHEMBL2554628 | 0.86 | HTR2A (0.41) | HTR2ADRD2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2553261 | 0.84 | SLC6A2 (0.46) | — | |
| SCHEMBL16390898 | 0.82 | SLC6A2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556074-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A. (IT) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124430-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-10-13 | — | — | WO | disclosed |