Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14633841 | 0.99 | CCR3 (0.46) | CCR3HTR2AHTR4HRH3ACHE | |
| SCHEMBL2557120 | 0.95 | CCR3 (0.46) | CCR3HTR2AHTR4HRH3ACHE | |
| SCHEMBL2555053 | 0.92 | SSTR5 (0.42) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL14633467 | 0.91 | KCNH2 (0.42) | KCNH2 | |
| Hydrochloric Acid SCHEMBL2554746 | 0.86 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL2554628 | 0.86 | HTR2A (0.41) | CCR3HTR2AHTR4KCNH2 | |
| SCHEMBL2556796 | 0.81 | TACR3 (0.46) | — | |
| SCHEMBL2551227 | 0.81 | SLC6A2 (0.47) | CCR3KCNH2 | |
| Hydrochloric Acid SCHEMBL14633798 | 0.80 | SLC6A2 (0.46) | CCR3 | |
| SCHEMBL2554766 | 0.80 | DRD2 (0.45) | HTR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556074-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A. (IT) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124430-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-10-13 | — | — | WO | disclosed |