Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 7/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573765 | 0.80 | GSK3B (0.59) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL19216470 | 0.80 | GSK3B (0.59) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL30548926 | 0.80 | GSK3B (0.59) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL4778699 | 0.76 | GSK3B (0.55) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL23501944 | 0.74 | GSK3B (0.50) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL14555908 | 0.74 | GSK3B (0.50) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL20371453 | 0.74 | GSK3B (0.50) | GSK3BKMT2APDK2PDK4BACE1 | |
| SCHEMBL1975325 | 0.74 | PLK4 (0.55) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL1973991 | 0.74 | PLK4 (0.55) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL31435686 | 0.72 | GSK3B (0.51) | GSK3BKMT2APDK2PDK4BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556070-A1 | SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES | University Health Network (CA) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011123947-A1 | SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |