Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 7/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19216470 | 0.81 | GSK3B (0.59) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL2573765 | 0.81 | GSK3B (0.59) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL30548926 | 0.81 | GSK3B (0.59) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL31435686 | 0.77 | GSK3B (0.51) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL23501944 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL14555908 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL28459489 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL2555060 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL20371453 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB | |
| SCHEMBL14487926 | 0.76 | GSK3B (0.50) | GSK3BPDK2PDK4PLK4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021422-A2 | PROCESS FOR THE PREPARATION OF INDOLIN-2-ONE DERIVATIVES USEFUL AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |