Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3011881 | 0.98 | CHRM1 (0.40) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| Hydrochloric Acid SCHEMBL3011878 | 0.96 | CHRM1 (0.42) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| SCHEMBL19959125 | 0.89 | CHRNB2 (0.39) | CHRM1CHRM2CHRM3SLC6A2SLC6A4 | |
| SCHEMBL1317639 | 0.88 | EPHX2 (0.38) | SLC6A2SLC6A4SLC6A3EPHX2CYP2D6 | |
| SCHEMBL27364707 | 0.86 | EPHX2 (0.40) | SLC6A2SLC6A4SLC6A3EPHX2CYP2D6 | |
| SCHEMBL17293853 | 0.83 | CHRM1 (0.36) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| SCHEMBL17765041 | 0.83 | CHRM1 (0.36) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| SCHEMBL16333287 | 0.83 | CHRM1 (0.36) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| SCHEMBL21469059 | 0.83 | CHRM1 (0.36) | CHRM1CHRM2CHRM3KCNH2SLC6A2 | |
| SCHEMBL17309259 | 0.83 | CHRM1 (0.36) | CHRM1CHRM2CHRM3KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |