Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | PGR | P06401 | 2/20 | 0.64 |
| ▸ | ESRRG | P62508 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | GBA1 | P04062 | 1/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
| ▸ | PRKCG | P05129 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2555743 | 1.00 | ESR1 (0.64) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL9857671 | 0.90 | ESR1 (0.80) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL9857878 | 0.90 | ESR1 (0.80) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL12282766 | 0.90 | ESR1 (0.59) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL12282851 | 0.90 | ESR1 (0.59) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL9857951 | 0.89 | ESR1 (0.78) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL12285440 | 0.87 | ESR1 (0.58) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL4364511 | 0.87 | ESR1 (0.78) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL4364513 | 0.87 | ESR1 (0.78) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL9857990 | 0.85 | ESR1 (0.70) | ESR1ESR2CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011129837-A1 | USE OF A 4-HYDROXYTOREMIFENE PRODRUG FOR TREATMENT OF BREAST CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2009120999-A2 | USE OF AN ENDOXIFEN PRODRUG FOR TREATMENT OF BREAST CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |