Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 2/20 | 0.67 |
| ▸ | HDAC1 known ✓ | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC2 known ✓ | Q92769 | 2/20 | 0.67 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.67 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valeric Acid SCHEMBL4734164 | 0.86 | CA1 (0.67) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL1035581 | 0.85 | FFAR3 (0.82) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL18039002 | 0.84 | FFAR3 (0.93) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL123022 | 0.84 | FFAR3 (0.93) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Stearic Acid SCHEMBL28189381 | 0.83 | FABP3 (0.58) | NFKB1GPR84CA1CES2CES1 | |
| Stearic Acid SCHEMBL6654230 | 0.83 | FABP3 (0.58) | NFKB1GPR84CA1CES2CES1 | |
| Succinic Acid SCHEMBL8148313 | 0.82 | CA1 (0.52) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL6837781 | 0.82 | FFAR3 (0.88) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL17261591 | 0.82 | FFAR3 (0.94) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL3045760 | 0.82 | FFAR3 (0.88) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2557939-B1 | COMPOSITIONS FOR ANIMAL FEED COMPRISING A BUTYRATE SALT | SANLUC INTERNAT NV (BE) | 2015-04-15 | — | — | EP | disclosed |
| EP-2557939-A1 | ANIMAL FEED FORMULATIONS COMPRISING BUTYRATE SALT | Sanluc International NV (BE) | 2013-02-20 | — | — | EP | disclosed |
| US-20130034629-A1 | ANIMAL FEED FORMULATIONS COMPRISING BUTYRATE SALT | SANLUC INTERNATIONAL N.V. (BE) | 2013-02-07 | — | — | US | disclosed |
| WO-2011128871-A1 | ANIMAL FEED FORMULATIONS COMPRISING BUTYRATE SALT | SANLUC INTERNATIONAL NV (BE) | 2011-10-20 | — | — | WO | disclosed |