Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8148315 | 0.86 | TP53 (0.58) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| L-Lactic Acid SCHEMBL37615 | 0.85 | — | — | |
| L-Lactic Acid SCHEMBL371442 | 0.85 | TP53 (0.50) | CA1CA4CA2NFKB1TP53 | |
| L-Lactic Acid SCHEMBL28859165 | 0.85 | TP53 (0.50) | CA1CA4CA2NFKB1TP53 | |
| L-Lactic Acid SCHEMBL2555976 | 0.82 | FFAR3 (0.67) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| L-Lactic Acid SCHEMBL25270068 | 0.82 | — | — | |
| L-Lactic Acid SCHEMBL1264937 | 0.82 | TP53 (0.47) | CA1CA4CA2NFKB1TP53 | |
| L-Lactic Acid SCHEMBL1264939 | 0.82 | — | — | |
| L-Lactic Acid SCHEMBL9688194 | 0.82 | TP53 (0.47) | CA1CA4CA2NFKB1TP53 | |
| L-Lactic Acid SCHEMBL2585779 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156226-A | Liquid and solid de-icing and anti-icing compositions and methods for making same | THERMO FIBERGEN, INC. (US) | 2000-12-05 | — | — | US | disclosed |