Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12288906 | 0.81 | SMN1; SMN2 (0.53) | HRH3KDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2573646 | 0.81 | SMN1; SMN2 (0.67) | HRH3KDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL2559530 | 0.71 | AOC3 (0.55) | — | |
| SCHEMBL12244840 | 0.71 | HRH3 (0.66) | HRH3PTPN11 | |
| SCHEMBL12244986 | 0.70 | HRH3 (1.00) | HRH3 | |
| SCHEMBL12244934 | 0.70 | HRH3 (0.65) | HRH3PTPN11 | |
| SCHEMBL12244842 | 0.70 | HRH3 (0.58) | HRH3PTPN11 | |
| SCHEMBL12244883 | 0.69 | HRH3 (0.67) | HRH3PTPN11 | |
| SCHEMBL12244482 | 0.69 | HRH3 (1.00) | HRH3 | |
| SCHEMBL12244806 | 0.69 | HRH3 (0.76) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | disclosed |