Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 10/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 7/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557199 | 0.82 | BRAF (0.43) | AOC3FYN | |
| SCHEMBL13606215 | 0.81 | AOC3 (0.52) | AOC3DHFRGRIN2B | |
| SCHEMBL2554399 | 0.79 | SMN1; SMN2 (0.61) | AOC3FYN | |
| SCHEMBL13680656 | 0.79 | AOC3 (0.51) | AOC3DHFRGRIN2B | |
| SCHEMBL2553959 | 0.79 | HRH4 (0.43) | — | |
| SCHEMBL2559391 | 0.79 | PIK3CA (0.51) | — | |
| SCHEMBL19496719 | 0.78 | AOC3 (0.69) | AOC3 | |
| SCHEMBL13606217 | 0.78 | CNR2 (0.51) | AOC3DHFR | |
| SCHEMBL13606218 | 0.77 | AOC3 (0.50) | AOC3DHFR | |
| SCHEMBL13606216 | 0.77 | KDM4E (0.56) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | disclosed |