Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561878 | 0.83 | PDE4D (0.41) | L3MBTL1ALDH1A1PDE4DPDE4APDE4B | |
| SCHEMBL12264390 | 0.83 | PDE4D (0.52) | MAPTTDP1L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL2553638 | 0.80 | PDE4A (0.38) | ALDH1A1NPSR1PDE4DPDE4APDE4B | |
| SCHEMBL2576433 | 0.78 | TSHR (0.47) | MAPTL3MBTL1ALDH1A1NPSR1PDE4D | |
| SCHEMBL14482912 | 0.71 | MEN1 (0.47) | ALDH1A1NPSR1PDE4DPDE4APDE4B | |
| SCHEMBL2563146 | 0.71 | ALDH1A1 (0.52) | MAPTALDH1A1NPSR1PDE4DTSHR | |
| SCHEMBL2555825 | 0.70 | PDE4D (0.63) | MAPTTDP1ALDH1A1NPSR1PDE4D | |
| SCHEMBL30929673 | 0.70 | ALDH1A1 (0.55) | MAPTTDP1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL2560863 | 0.70 | ALDH1A1 (0.55) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12264383 | 0.69 | PDE4D (0.47) | L3MBTL1ALDH1A1NPSR1PDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552895-B1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms Universität Münster (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2552895-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms-Universität Münster (DE) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120861-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2011-10-06 | — | — | WO | disclosed |