Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 13/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.56 |
| ▸ | RET | P07949 | 15/20 | 0.55 |
| ▸ | ROS1 | P08922 | 15/20 | 0.55 |
| ▸ | FLT3 | P36888 | 15/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | BUB1 | O43683 | 1/20 | 0.48 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LATS1 | O95835 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25563915 | 0.95 | FLT3 (0.59) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25563923 | 0.92 | FLT3 (0.52) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25562320 | 0.91 | EML4 (0.57) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25566574 | 0.91 | EML4 (0.67) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25563917 | 0.91 | EML4 (0.53) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25563924 | 0.91 | FLT3 (0.52) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25563907 | 0.89 | EML4 (0.54) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25562264 | 0.88 | EML4 (0.58) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25566908 | 0.87 | EML4 (0.53) | EML4ALKRETROS1FLT3 | |
| SCHEMBL25562404 | 0.86 | EML4 (0.61) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167099-A1 | NEW PYRAZINE COMPOUND | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-06-01 | — | — | US | disclosed |
| US-20230167099-A1 | NEW PYRAZINE COMPOUND | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167099-A1 | NEW PYRAZINE COMPOUND | EGFR, ERBB2, WEE1 | EML4 163/4885ALK 131/4885RET 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.