Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25566505 | 0.90 | CHRM2 (0.38) | CHRM2CHRM1CHRM3KDM1ADDB1 | |
| SCHEMBL30977192 | 0.90 | CHRM2 (0.39) | CHRM2CHRM1CHRM3SPHK1KDM1A | |
| SCHEMBL30977195 | 0.90 | CHRM2 (0.39) | CHRM2CHRM1CHRM3SPHK1KDM1A | |
| SCHEMBL25257754 | 0.90 | CHRM2 (0.39) | CHRM2CHRM1CHRM3SPHK1KDM1A | |
| SCHEMBL25242987 | 0.88 | CHRM2 (0.36) | CHRM2CHRM1CHRM3KDM1ADDB1 | |
| SCHEMBL31712392 | 0.87 | CHRM2 (0.38) | CHRM2CHRM1CHRM3SPHK1DDB1 | |
| SCHEMBL30998687 | 0.87 | CHRM2 (0.39) | CHRM2CHRM1CHRM3SPHK1KDM1A | |
| SCHEMBL25216428 | 0.86 | CHRM2 (0.38) | CHRM2CHRM1CHRM3KDM1ADDB1 | |
| SCHEMBL26366228 | 0.86 | CHRM2 (0.38) | CHRM2CHRM1CHRM3KDM1ADDB1 | |
| SCHEMBL30067317 | 0.85 | MEN1 (0.35) | CHRM2CHRM1CHRM3SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4442686-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd (CN) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023098425-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |