SCHEMBL25567327

SCHEMBL25567327

Cc1cccc2c(C3CCC(=O)NC3=O)n[nH]c12

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 20/20 0.55
▸ CRBN Q96SW2 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29321878 0.81 DDB1 (0.46) DDB1CRBN
SCHEMBL20805224 0.80 DDB1 (0.58) DDB1CRBN
SCHEMBL30273914 0.80 DDB1 (0.58) DDB1CRBN
SCHEMBL25027088 0.76 DDB1 (0.77) DDB1CRBN
SCHEMBL23553542 0.75 CRBN (0.47) DDB1CRBN
SCHEMBL31433918 0.74 DDB1 (0.41) DDB1CRBN
SCHEMBL459725 0.71 DDB1 (1.00) DDB1CRBN
SCHEMBL31426276 0.70 IDO1 (0.47) DDB1CRBN
SCHEMBL30734852 0.70 CRBN (0.59) DDB1CRBN
SCHEMBL24818017 0.70 DDB1 (0.47) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023083194-A1 WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF 杭州格博生物医药有限公司 2023-05-19 — — WO disclosed
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