Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.47 |
| ▸ | ROS1 | P08922 | 10/20 | 0.47 |
| ▸ | FLT3 | P36888 | 10/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25562707 | 0.87 | RET (0.59) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573690 | 0.82 | RET (0.43) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573679 | 0.82 | RET (0.45) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573703 | 0.81 | RET (0.45) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573721 | 0.81 | RET (0.43) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573697 | 0.80 | RET (0.45) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25573714 | 0.80 | RET (0.44) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25569729 | 0.78 | EML4 (0.40) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562720 | 0.77 | EML4 (0.67) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562778 | 0.75 | EML4 (0.56) | RETROS1FLT3ALKEML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167099-A1 | NEW PYRAZINE COMPOUND | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167099-A1 | NEW PYRAZINE COMPOUND | EGFR, ERBB2, WEE1 | RET 22/4885ROS1 31/4885FLT3 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.