Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetazolamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 16/20 | 1.00 |
| ▸ | CA2 known ✓ | P00918 | 16/20 | 1.00 |
| ▸ | CA4 known ✓ | P22748 | 9/20 | 1.00 |
| ▸ | CA12 known ✓ | O43570 | 4/20 | 1.00 |
| ▸ | CA9 | Q16790 | 10/20 | 1.00 |
| ▸ | CA3 | P07451 | 4/20 | 1.00 |
| ▸ | CA6 | P23280 | 4/20 | 1.00 |
| ▸ | CA5A | P35218 | 4/20 | 1.00 |
| ▸ | CA7 | P43166 | 4/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CA11 | O75493 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetazolamide SCHEMBL23219 | 1.00 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL15513954 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL11301585 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL2845106 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL30094028 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL1998362 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL28346552 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL40812 | 0.98 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL20553201 | 0.97 | CA1 (0.93) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL9390276 | 0.97 | CA1 (0.93) | CA1CA2CA9CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109288986-A | A kind of drug and preparation method thereof for glaucoma treatment | 纪霞 | 2019-02-01 | — | — | CN | claimed |
| EP-3209331-A1 | OPHTHALMIC SOLUTION | Sentiss Pharma Private Limited (IN) | 2017-08-30 | — | — | EP | claimed |
| EP-3209331-B1 | OPHTHALMIC SOLUTION | SENTISS PHARMA PRIVATE LTD (IN) | 2023-07-12 | — | — | EP | disclosed |
| WO-2021155781-A1 | BENZENE SULFONAMIDE COMPOUND CONTAINING FIVE-MEMBERED HETEROCYCLE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2021-08-12 | — | — | WO | disclosed |
| CN-109288986-A | A kind of drug and preparation method thereof for glaucoma treatment | 纪霞 | 2019-02-01 | — | — | CN | disclosed |
| CN-109288986-A | A kind of drug and preparation method thereof for glaucoma treatment | 纪霞 | 2019-02-01 | — | — | CN | disclosed |
| CN-108904486-A | PT2385 is used to prepare the purposes of prevention and treatment altitude erythrocytosis drug | 大连天星生物技术有限责任公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-108721515-A | One kind is for treating hydrocephalic Chinese medicine | 淄博齐鼎立专利信息咨询有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-104684574-B | Peptide antagonists of the vasopressin-2 receptor | 原子能与替代能源署 | 2018-08-31 | — | — | CN | disclosed |
| CN-108210683-A | Pharmaceutical composition for treating glaucoma | 浙江衢化医院（浙江省医疗健康集团衢州医院） | 2018-06-29 | — | — | CN | disclosed |
| CN-108030074-A | Improve complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof | 石元刚 | 2018-05-15 | — | — | CN | disclosed |
| CN-104013622-A | Novel use of methazolamide | INST HYGIENE & ENVIRONMETNAL MEDICINE ACADEMY MILITARY MEDICAL SCIENCES | 2014-09-03 | — | — | CN | disclosed |
| EP-2555994-A1 | DELIVERY SYSTEM FOR DISPENSING METERED VOLUMES OF PURE OR STERILE FLOWABLE SUBSTANCES | Reseal International Limited Partnership (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011126569-A1 | DELIVERY SYSTEM FOR DISPENSING METERED VOLUMES OF PURE OR STERILE FLOWABLE SUBSTANCES | RESEAL INTERNATIONAL LIMITED PARTNERSHIP (US) | 2011-10-13 | — | — | WO | disclosed |
| EP-1931760-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | The University of Alabama (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044693-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | THE UNIVERSITY OF ALABAMA (US) | 2007-04-19 | — | — | WO | disclosed |
| US-5944021-A | Therapeutic use of a carbonic anhydrase enzyme inhibitor for the treatment of brain edema | RODRIGUEZ VICTORIO C (US) | 1999-08-31 | — | — | US | disclosed |
| US-5755237-A | Therapeutic use of acetazolamide for the treatment of brain edema | RODRIGUEZ VICTORIO C (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0776182-A1 | THERAPEUTIC USE OF ACETAZOLAMIDE FOR THE TREATMENT OF BRAIN EDEMA | Rodriguez, Victorio C. (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1996039978-A1 | THERAPEUTIC USE OF ACETAZOLAMIDE FOR THE TREATMENT OF BRAIN EDEMA | RODRIGUEZ VICTORIO C (US) | 1996-12-19 | — | — | WO | disclosed |