Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetazolamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 16/20 | 0.97 |
| ▸ | CA2 known ✓ | P00918 | 16/20 | 0.97 |
| ▸ | CA4 known ✓ | P22748 | 9/20 | 0.97 |
| ▸ | CA12 known ✓ | O43570 | 4/20 | 0.97 |
| ▸ | CA9 | Q16790 | 10/20 | 0.97 |
| ▸ | CA3 | P07451 | 4/20 | 0.97 |
| ▸ | CA6 | P23280 | 4/20 | 0.97 |
| ▸ | CA5A | P35218 | 4/20 | 0.97 |
| ▸ | CA7 | P43166 | 4/20 | 0.97 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.97 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.97 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CA11 | O75493 | 1/20 | 0.97 |
| ▸ | THRB | P10828 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetazolamide SCHEMBL2557036 | 0.98 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL23219 | 0.98 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL40812 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL11301585 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL2845106 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL1998362 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL30094028 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL15513954 | 0.97 | CA1 (0.97) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL20553201 | 0.95 | CA1 (0.93) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL9390276 | 0.95 | CA1 (0.93) | CA1CA2CA9CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536500-B | Selective matrix metalloproteinase inhibitors | 圣母大学 | 2020-01-10 | — | — | CN | disclosed |