Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557912 | 0.92 | PDE10A (0.46) | PDE10ACYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL2563205 | 0.89 | PDE10A (0.53) | PDE10ACYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL2559772 | 0.89 | PDE10A (0.53) | PDE10ACYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL2556902 | 0.88 | PDE10A (0.54) | PDE10ACYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL2560840 | 0.86 | PDE10A (0.46) | PDE10APOLBTP53MAPTNPSR1 | |
| SCHEMBL7707934 | 0.83 | PDE10A (0.40) | PDE10APOLBTP53MAPTNPSR1 | |
| SCHEMBL2576250 | 0.80 | PDE10A (0.46) | PDE10ACYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL2575117 | 0.79 | PDE10A (0.52) | PDE10ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2575124 | 0.78 | PDE10A (0.55) | PDE10ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2557084 | 0.78 | CYP19A1 (0.42) | PDE10ACYP19A1CYP11B1CYP11B2GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |