Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556902 | 0.90 | PDE10A (0.54) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2559772 | 0.89 | PDE10A (0.53) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2563205 | 0.89 | PDE10A (0.53) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2559622 | 0.89 | PDE10A (0.54) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2575124 | 0.88 | PDE10A (0.55) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2554081 | 0.85 | PDE10A (0.53) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2557912 | 0.81 | PDE10A (0.46) | PDE10ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2559770 | 0.81 | PDE10A (0.63) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2560840 | 0.81 | PDE10A (0.46) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2557293 | 0.79 | PDE10A (0.43) | PDE10ACYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |