SCHEMBL2557487

SCHEMBL2557487

O=Cc1c(-c2ccc(Cl)cc2)nn(-c2cc(F)cc(F)c2)c1Br

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.40
SRC P12931 2/20 0.38
BRAF P15056 2/20 0.38
KDR P35968 2/20 0.38
NPSR1 Q6W5P4 2/20 0.36
GAA P10253 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
PTGS2 P35354 2/20 0.33
DHODH Q02127 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
POLB P06746 1/20 0.33
PTGS1 P23219 2/20 0.32
FAAH O00519 1/20 0.32
KCNH2 Q12809 1/20 0.32
CCNE1 P24864 1/20 0.32
CDK2 P24941 1/20 0.32
SMPD1 P17405 2/20 0.32
RIPK2 O43353 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15332036 0.91 POLB (0.40) LMNASRCBRAFKDRNPSR1
SCHEMBL2553532 0.90 LMNA (0.40) LMNASRCBRAFKDRNPSR1
SCHEMBL2560836 0.88 LMNA (0.49) LMNASRCBRAFKDRNPSR1
SCHEMBL15332622 0.87 CA1 (0.36) PTGS2POLBPTGS1
SCHEMBL2554411 0.87 POLB (0.39) LMNASRCBRAFKDRNPSR1
SCHEMBL2562810 0.86 GRM5 (0.35) LMNANPSR1MEN1KMT2APTGS2
SCHEMBL15329615 0.86
SCHEMBL15331822 0.86 LMNA (0.40) LMNASRCBRAFKDRNPSR1
SCHEMBL15331787 0.84 CA1 (0.40) LMNASRCBRAFKDRNPSR1
SCHEMBL2562771 0.83 PPP1CA (0.45) LMNASRCNPSR1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed