SCHEMBL2558008

SCHEMBL2558008

CN(C)c1cccc(-c2cc(N3CCCCC3)ncn2)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.66
TSHR P16473 2/20 0.66
NPC1 O15118 1/20 0.66
RECQL P46063 1/20 0.66
RAB9A P51151 1/20 0.66
CYP1A2 P05177 6/20 0.57
HSD17B10 Q99714 4/20 0.57
ALDH1A1 P00352 3/20 0.57
HPGD P15428 3/20 0.57
KDM4E B2RXH2 2/20 0.57
GLA P06280 2/20 0.57
MAPT P10636 2/20 0.57
HRH4 Q9H3N8 1/20 0.52
CNR1 P21554 1/20 0.43
ALOX15 P16050 3/20 0.42
LMNA P02545 2/20 0.41
CYP2C19 P33261 2/20 0.41
TP53 P04637 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2557161 0.81 SMN1; SMN2 (0.64) SMN1; SMN2TSHRNPC1RECQLRAB9A
SCHEMBL12289499 0.81 SMN1; SMN2 (0.51) SMN1; SMN2TSHRNPC1RECQLRAB9A
Hydrochloric Acid SCHEMBL11787343 0.79 SMN1; SMN2 (0.97) SMN1; SMN2TSHRNPC1RECQLRAB9A
Hydrochloric Acid SCHEMBL11786227 0.79 SMN1; SMN2 (0.97) SMN1; SMN2TSHRNPC1RECQLRAB9A
SCHEMBL27732905 0.78 SMN1; SMN2 (0.97) SMN1; SMN2TSHRNPC1RECQLRAB9A
Hydrochloric Acid SCHEMBL11783697 0.77 SMN1; SMN2 (0.94) SMN1; SMN2TSHRNPC1RECQLRAB9A
SCHEMBL2553959 0.75 HRH4 (0.43) SMN1; SMN2TSHRNPC1RECQLRAB9A
SCHEMBL2559391 0.75 PIK3CA (0.51) TSHRCYP1A2HSD17B10KDM4ECNR1
SCHEMBL2559530 0.74 AOC3 (0.55)
SCHEMBL19548104 0.69 SMN1; SMN2 (0.61) SMN1; SMN2TSHRNPC1RECQLRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011130515-A1 ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-10-20 WO disclosed