Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.44 |
| ▸ | JAK3 | P52333 | 15/20 | 0.44 |
| ▸ | JAK1 | P23458 | 10/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175246 | 1.00 | JAK2 (0.44) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL173820 | 0.80 | JAK2 (0.68) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL174882 | 0.80 | JAK2 (0.50) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL256500 | 0.80 | JAK2 (0.68) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL10232408 | 0.80 | JAK2 (0.50) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL15205290 | 0.80 | JAK2 (0.62) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL164919 | 0.80 | JAK2 (0.62) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL15205291 | 0.80 | JAK2 (0.62) | JAK2JAK3JAK1CYP3A4CYP2C8 | |
| SCHEMBL174517 | 0.78 | FLT3 (0.40) | JAK2JAK3JAK1CYP2C9CYP2C19 | |
| SCHEMBL174790 | 0.66 | JAK2 (0.68) | JAK2JAK3JAK1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |