Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 10/20 | 0.36 |
| ▸ | JAK3 | P52333 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174455 | 0.80 | AURKA (0.42) | FLT3MAPTAURKAAURKBALDH1A1 | |
| SCHEMBL174958 | 0.80 | AURKA (0.59) | AURKAAURKBJAK2JAK3JAK1 | |
| SCHEMBL175132 | 0.80 | AURKA (0.53) | MAPTAURKAAURKBALDH1A1JAK2 | |
| SCHEMBL175246 | 0.78 | JAK2 (0.44) | FLT3AURKAALDH1A1JAK2JAK3 | |
| SCHEMBL255873 | 0.78 | JAK2 (0.44) | FLT3AURKAALDH1A1JAK2JAK3 | |
| SCHEMBL167507 | 0.74 | ALDH1A1 (0.44) | FLT3MAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL174808 | 0.67 | AURKA (0.60) | AURKAAURKBJAK2JAK3JAK1 | |
| SCHEMBL165427 | 0.65 | AURKA (0.60) | AURKAAURKBJAK2JAK3JAK1 | |
| SCHEMBL166330 | 0.63 | AURKA (0.54) | AURKAAURKBJAK2JAK3JAK1 | |
| SCHEMBL175237 | 0.62 | AURKA (0.64) | AURKAAURKBJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |